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The clinical features of Se toxicity mainly include brittle hair and nail loss, gastrointestinal disorders, rash, rickets and neurological disorders (116)

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Subsequent gene-expression analyses cited in the review identified GHK-Cu as modulating expression of approximately one-third of human genes, with a pattern consistent with reversal of age-related transcriptomic shifts

Hence the role of GPX3 in tumor progression is controversial and further mechanistic studies are needed to achieve specific targeting