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Data Availability Statement The raw datasets generated and statistically analyzed for the present study comprise several appendix with individual records and can be made available from the corresponding author on reasonable request

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

J Biol Chem 277:2694426949

Notably, 2-O-methyl (2-OMe) (Fig

However, p21 also affects the cellular antioxidant response, possibly by altering the stability and function of nuclear factor erythroid 2-related factor 2 (NRF2), which is a key regulator of antioxidant genes (136,137)