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Carnitine levels are normally less depleted in secondary carnitine deficiency when compared to OCTN2-deficient patients, and therefore smaller doses of L-carnitine can restore the carnitine levels in a shorter period of time than in patients with primary deficiency [41]

The most important flavonoids contained in propolis are the following: galangin, quercetin, apigenin, acacetin, catechin, chrysin, luteolin, kaempferol, pinocembrin, myricetin, naringenin, and rutin [105]

doi: 10.1053/ajkd.2003.50099

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Nevertheless, the clinical application of current metabolism-targeting drugs remains limited by issues such as low bioavailability, poor solubility, and insufficient targeting specificity, preventing their antitumor efficacy from being fully realized