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The ability of these molecules to interact simultaneously with both cholinergic and amyloidogenic targets supports their potential role as dual-target inhibitors, a highly desirable strategy in Alzheimers disease management

In particular, the canonical NF-B pathway, which controls several aspects of cell growth and survival, inflammation, and immune response, is implicated in the regulation of thyroid physiology, participating in the expression of various thyroid-specific genes, including NIS , PAX8 , TG , TPO , and TTF-1 , and also contributes to the development of several neoplasms, including TC, enhancing the proliferation and viability of thyroid neoplastic cells and their potential to migrate and colonize distant sites [128,129,130]

In addition, with exception of Streptococcus pneumoniae, 7 motif blocks were conserved across 4 T1D related bacterial species and 6 gut bacterial species

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Treatment with the flavonoid 7,8-Dihydroxyflavone: a promising strategy for a constellation of body and brain disorders