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7 Novel and Emerging Therapies One approach to avoiding gastrointestinal toxicity of NSAIDs is to pair them with fixed doses of gastroprotective agents in single-tablet formulations

Olaparib is a compound that effectively inhibits PARP1 and PARP2, binding to the catalytic domain and preventing the transfer of ADP-ribose units from NAD + to target proteins, thus lowering NAD + consumption 160,161

An increase in metHb levels and in its linkage to the RBC membrane, accompanied by ROS formation, was also found in stored RBCs for blood transfusion [30] and in exogenous H 2 O 2 -induced OS upon healthy erythrocytes [31, 32]

10 This is a particularly noteworthy hallmark because GSH depletion is reflective of a decrease in the synthesis of proteoglycan and type II collagen in chondrocytes