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TMAO promotes macrophage infiltration and activation within adipose tissue, driving a shift in macrophage phenotype toward the pro-inflammatory M1 state, contributing to adipose tissue dysfunction, a key hallmark of obesity-related metabolic dysfunction [30, 75]

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J Neurosci 23:58165826 [DOI] [PMC free article] [PubMed] [Google Scholar] Li C, Ford ES, Zhao G, Balluz LS, Giles WH, Liu S (2011a) Serum alpha-carotene concentrations and risk of death among US adults: The third national health and nutrition examination survey follow-up study

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