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Description
Overexpression of GPX1 attenuates 6-OHDA induced toxicity to dopamine neurons in rodent models of PD [11, 12]
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High doses, repeated administration, vulnerable populations (pregnant animals), and sensitive tissues (gastrointestinal tract, reproductive organs) have all been evaluated
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It can generally be agreed that prophylactic therapeutic approaches delivered as a combinatorial regimen co-initiated alongside ERT rather than single agent therapies are probably the most effective strategy for prevention of HSATs [158160]
