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Those results revealed that stimulation of primary human umbilical vein ECs with ADRB2 agonist, isoprenaline, activates a proangiogenic pathway through upregulation of PlexinA1 and VEGFR2, which was associated with enhanced Janus kinase 2 (JAK2)-STAT3 phosphorylation [201]

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NaBPC157 (10 g or 10 ng/kg b.w., i.p.) or saline (5.0 ml/kg b.w., i.p.) was applied either 1 hour before or 1 hour after both carotid arteries were ligated for 3 or 6 hours in rats