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The main mechanisms include stimulating the expression of follicle-related growth factors, dilating scalp blood vessels and improving microcirculation, boosting the differentiation and proliferation of hair follicle epithelial cells, and activating the Wnt/-Catenin signaling pathway and its key proteins (Scheme 2)

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Peptide therapeutics have emerged as promising agents in gerontological medicine, targeting multiple hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis (protein homeostasis), mitochondrial dysfunction, and cellular senescence ( This review examines nine peptides with demonstrated or potential applications in age-related conditions: tirzepatide, epitalon, GHK-Cu, BPC-157, TB-500, Semax, CJC-1295, ipamorelin, and bremelanotide (PT-141)