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BC-box proteins such as ZSWIM8 are only known to function with CUL2 or CUL5 (refs

This is especially important for individuals exposed to toxins and pollutants common in Lebanon

Martnez-Soto JC, Domingo JC, Cordobilla B, Nicols M, Fernndez L, Albero P, et al

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In contrast, the sibling (who also carries the L68Q mutation and was not on NAC between biopsies #1 and #2) showed significant progression in immunoreactivity, reflective of an increase in hCC protein complex deposition in the skin