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Although it is well known that leptin plays a central role in regulating energy balance by suppressing food intake and promoting energy expenditure, the existence of leptin resistance in majority of obese individuals hampers the utilization of leptin therapy against these disorders

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[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Magalhes P.V., Dean O.M., Bush A.I., Copolov D.L., Malhi G.S., Kohlmann K.K., Jeavons S., Schapkaitz I., Anderson-Hunt M.D., Berk M