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Therapeutic Research Protocol Dose: 10 20 mg (= 3061 clicks) Duration: 4 6 weeks Frequency: Daily Cycle Interval: 4-week interval Goal / Description: Modeled on extended NNMT inhibition protocols in DIO models

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The combination treatment reduced body weight on average by 12.7%, significantly more than treatment with pramlintide alone (8.4%), which is interpreted as 10 pounds more weight loss with the combined treatment