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The National Institute on Aging Interventions Testing Program evaluates agents hypothesized to increase healthy lifespan in genetically heterogeneous mice ( As of Cohort 11, C2017, nine agents have shown significant extension of median lifespan: acarbose, aspirin, canagliflozin, captopril, glycine, nordihydroguaiaretic acid, Protandim, rapamycin, and 17-estradiol [82,83,84,85,86,87,88,89,90]

Tau seeding, also present in AD (123, 311, 372376), has been reported in the brains of MS patients (140) and this tau deposition may produce demyelination through injury to oligodendrocytes (128)

Ma X, Zhang Y, Yang Y, Liu X, Yang Z, Bao X, et al

doi: 10.1001/archpedi.1987.04460060076039

Enrichment of mitochondrial complex I V was assessed in fractions AC by Western blot using antibody to mitochondrial complex I V (Mitosciences, Eugene, Oregon)