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Circulation Research

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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of IDH1 and IDH2, changes in glutaminolysis that deplete KG, or alterations in fumarate hydratase (FH) and succinate dehydrogenase (SDH) that inhibit KGDD activity (Losman et al., 2020)