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Biohacker Protocol (experimental) Dose: 0.25 mg (= 10 clicks) Duration: Continuous Frequency: Twice daily Cycle Interval: No fixed interval / take 1 week off every 8 weeks Goal / Description: Micro-dosing approach focusing on steady fat metabolism

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Introduction Cyclodextrins have currently become extremely important in the pharmaceutical industry due to their versatility in improving the stability, solubility and bioavailability of various active substances [1]

We therefore also explored the cumulative metformin exposure by obtaining the Metformin 1-year cumulative dose (g/year)

To move Epitalon from experimental to evidence-based, several developments are essential: Randomized, double-blind, placebo-controlled clinical trials, ideally targeting specific endpoints (sleep, immune aging, telomere attrition) Toxicology and long-term safety studies, including exploration of stereoisomer effects and off-target consequences Validated delivery systems (e.g., dendrimer-conjugates, transdermal patches) that make real-world use feasible Pharmacodynamic biomarkers, to identify responders and track efficacy objectively over time Epitalon is not snake oil, but its also not a magic bullet