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The substrates and products of the DHODH reaction have opposite effects on ferroptosis, suggesting that the potential role of DHODH in regulating ferroptosis sensitivity is independent of its function of producing pyrimidine nucleotides
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Therefore, molecules that regulate the immune balance of CD8+ T cell subpopulations and related signaling pathways are potential therapeutic targets for LN
According to the World Obesity Atlas 2022, it is predicted that by 2030, one out of every three women and one out of every seven men will be classified as obese (Chand et al., 2024)
Based on omics and molecular biology, abnormal energy metabolism, oxidative stress and mitochondrial dysfunction serve a central role in the pathogenesis of fatigue
