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The protein accommodates up to six Cd 2+ together with four S 2

(2003) Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts

Challenges in scalable, GMP-compliant manufacturingparticularly batch-to-batch variability in encapsulation efficiency (2194% for PLGA NPs)and long-term biocompatibility assessments (e.g., hepatosplenic accumulation, PEG immunogenicity) remain unresolved

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Future studies should adopt targeted designs to mitigate these issues: Confounding by coexisting nutrient deficiencies: mineral deficiencies [e.g., zinc (344)] or vitamin deficiencies [e.g., vitamin D (169, 347349)] often co-occur with protein or fiber deficiencies