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4.5.5 Sustained-release formulations Sustained-release technologies, such as hydrogels and microspheres, provide a regulated release of curcumin, reducing dose-dependent toxicity and sustaining therapeutic levels over prolonged durations

10.3389/fnmol.2017.00377 142

Hilton, M

However, if you have extremely reactive skin, do a patch test first before regular use

The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect
