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In clinical settings, giving DSIP intravenously has been shown to reduce pain in most patients with chronic pain, including those with migraines and psychogenic pain

Potenitally consistent with this expression pattern, NMDAR responses in regular-spiking radiatum interneurons were found to be senstive to inhibition by the GluN2B NAM Ro 25-6981, whereas this compound had no effect on responses in fast-spiking, presumabley PV expressing, neurons in the hippocampus [81]