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However, a 2025 systematic review (seven studies, n=12,247) reported that the incidence of persistent pain after hysterectomy ranged from 12% to 68%, with most studies around 25%, indicating that hysterectomy is not always curative

FDA should follow the early lead of EMA and adopt greater transparency with regard to regulatory rationale for approval or disapproval of marketing authorization submissions for rare disease drug products
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Beyond the direct financial cost, there is the opportunity cost
