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FIGURE 7 5.1 Curcumin liposomes Since curcumin is a difficult drug to dissolve in water, liposomes were prepared to improve the water solubility and bioavailability of curcumin

Additionally, it reversibly acetylates the K1371 site on TSC2, boosting how well its GAP domain interacts with Rheb.Isotope tracing experiments have confirmed that in GCN5L knockout cells grown in an amino acid-free medium, the activity of glutamine synthetase (GLUL) decreases, while the production of -ketoglutarate dependent on glutamate dehydrogenase (GLUD1) is reduced, resulting in the disruption of the tricarboxylic acid cycle metabolic flow (Miao, 2023)

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The results indicated the absence of dose-limiting toxicity at the maximum delivered dose, including no hematologic, kidney, ophthalmic, or nervous toxicities (Wittgen et al., 2007)