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Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase C in triggering hepatic insulin resistance

GSS AA Sequence ATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV Predicted Molecular Mass 53.5 kDa Molecular Weight Approximately 55 kDa, based on SDS-PAGE under reducing conditions

Consequently, cysteine availability and the resulting GCS activity are both pivotal for GSH re-synthesis and therefore provide an indication of the models potential to recover GSH levels 21

doi:10.1378/chest.09-0319

Aber klingt gut ist keine klinische Evidenz und auch kein Ersatz dafr