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Description
In TNBS colitis, a major contributor to the hyperexcitability in AH neurons is an increase in a hyperpolarization-activated cation conductance ( I h , due to hyperpolarization-activated cyclic nucleotide-gated channels), with no change in the IK Ca (633)

W.ChoT.PrasadS.KojicL.et al (2009)

Many factors cause insomnia, and insomnia may also be a symptom of another medical condition, such as depression

Yes, in appropriate patients
Dose adjustments are made based on both lab values and how you're feeling
