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Special populations Certain groups should exercise caution when taking vitamin B12 supplements: Pregnant and breastfeeding women : Vitamin B12 is required during pregnancy and breastfeeding to prevent cognitive and developmental delays, but taking only the recommended amounts is essential

Conclusions Based on very low quality evidence, there does appear to be an association between elevated plasma homocysteine levels (a by-product of B vitamins) and the onset of dementia

Severe loss of quality of life, due to symptoms such as debilitating fatigue, insomnia (B12 is required for synthesis of melatonin), mental illness, and neurological symptoms

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