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Different levels of ROS cause different effects

To date, three patterns of p-i-related hypersensitivity reactions have been proposed: the altered peptide model of p-i HLA, the allo-immune model of p-i HLA, and the p-i TCR model ( The altered peptide model of p-i HLA and the allo-immune model of p-i HLA were both developed because some ADRs generated by small molecule drugs are limited exclusively to the HLA allele (36)

Therefore, manipulating the uptake and metabolism of lipids, including glycerophospholipids and cholesterol, may be an effective means of sensitising MM cells to ferroptosis

Quantitative RT-PCR Total RNA was extracted using PureLink RNA isolation (Life Technologies, 12183025) and treated with DNase (Life Technologies, AM2222)