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For example, those with severe liver or kidney impairment, unstable heart disease, or other significant systemic illnesses are typically approached carefully if considering NAD+ therapy

An omnibus test of the primary outcome was statistically significant (P = .006)

Some people experience headaches during the first week or two at this dose level, which typically resolve as the body adjusts

102,125 In a study that included 113 military personnel exposed to loud noise, B12 deficiency was detected in 47% of those with tinnitus plus noise-induced hearing loss, 27% of those with noise-induced hearing loss only, and 19% of those with normal hearing, suggesting B12 deficiency may be associated with risk of developing tinnitus

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