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Some studies indicate people with obesity have low vitamin B12 levels

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Some patients choose to delay their next dose by 12 days to manage systemic symptoms, but this minor gap does not affect weight loss results

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk