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What they found: NR is rapidly absorbed orally , peak at 30 minutes NR is converted to NAD+ in multiple tissues , liver, muscle, blood Plasma NAD+ rises 2 to 8 after a single dose Optimal dosing regimens: 100 to 1000 mg No accumulation of toxic metabolites Why it matters: This is the reference pharmacokinetic publication for NR and NMN

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CV safety is currently under investigation for tirzepatide in patients with obesity without diabetes (NCT05556512) and for cagrilintide/semaglutide with overweight and obesity with and without diabetes (NCT05669755)

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