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With the exception of the freeze response, which is mediated by the PNS and neurotransmitter acetylcholine, the fight-or-flight response is mostly executed by glucocorticoids (GCs) and catecholamines (CAs)

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While it is possible that the patients immune response, specifically the b-cell and memory T cell responses, could have contributed to the negative outcome, researchers suggest that administering the drug within 27 days or less before transplantation may have adverse effects on the transplanted organ