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Additionally, this study revealed an immunosuppressive TME in brain metastases characterized by reduced CD8 + Tcell infiltration, increased numbers of Treg cells, and reprogrammed myeloid cell populations [277]

doi: 10.3389/fphys.2025.1609555 Received 14 April 2025 Accepted 02 September 2025 Published 18 September 2025 Corrected 28 October 2025 Volume 16 - 2025 Edited by Samad Rahimnejad, University of Murcia, Spain Reviewed by Palash Kumar Pal, University of Calcutta, India Updates Copyright 2025 Kovacik, Helczman, Tomka, Jambor, Kovacikova and Arvay
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