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Contraction of smooth muscle is mediated by the release of calcium, while relaxing effects are mediated by the generation of cAMP

Additionally, it promotes stem cell activity, supports bone repair, and has shown neuroprotective benefits against age-related cognitive decline in animal models 1,3

Deavall DG, Martin EA, Horner JM (2012) Roberts R (2012) Drug-Induced Oxidative Stress and Toxicity

Dehydration makes nausea significantly worse For diarrhea: Increase fiber intake gradually, not suddenly Stay hydrated with electrolyte solutions, not just plain water Avoid sugar alcohols and artificial sweeteners, which can worsen GI symptoms For constipation: Increase water intake to at least 2-3 liters daily Add magnesium citrate if needed (a gentle, effective option) Include high-fiber vegetables and fruits in your diet When to slow the escalation If you experience side effects that significantly impact your daily function, extend the current dose phase by 2-4 additional weeks before escalating

76,77 Proliferation of astrocytes is an indispensable part of reactive astrogliosis, and suppression of proliferation exacerbates damage and delays wound closure