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A pilot randomized clinical trial (RCT) testing PD patients to maintain a low-fat or ketogenic diet for 8 weeks observed that both groups significantly improved in motor and nonmotor symptoms, but the ketogenic group showed greater improvements in nonmotor symptoms (Phillips et al., 2018)

More recently, however, another polymorphic genotype has been reported that results in ultrarapid metabolism of relevant drugs due to the presence of 2D6 allelic variants with up to 13 gene copies in tandem