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( A and B ) Dot plot of scRNA-Seq data ( showing geometric mean expression (log[TP10K+1]) and frequency (dot size) of key genes associated with GSH metabolism in clusters of tumor-infiltrating CD3 + and/or CD8 + T cells from patients with breast cancer ( n = 26), renal carcinoma ( n = 8), melanoma ( n = 59), and colon cancer ( n = 62)

Liu Y, Tan J, Ou S, Chen J, Chen L

These results thus indicate that Chac2 knockdown impairs GSH accumulation and attenuates N1-type inflammatory polarization

doi: 10.1089/thy.2016.0397 39 BurchHBLahiriSBahnRSBarnesS

1 Introduction Cancer is a complex genetic disease, and multiple genetic and environmental factors have influenced its occurrence and development