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Confounding factors and mitigation strategies in the study of acylcarnitine biomarkers in DKD Core confounding factors The interpretation of acylcarnitine levels is influenced by multiple confounding factors that must be carefully considered in both research design and clinical practice

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Serum TC, HDL-C, LDL-C, and TG concentrations are approximately 3% higher than in plasma

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DHT differs from testosterone by the absence of a single double bond on ring A (Figure 3A) 13 , which increases its affinity for the AR two-fold and decreases the rate of dissociation five-fold relative to testosterone 66 , differences that account for essential, DHT-specific functions