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The neurological effects can worsen, potentially leading to permanent cognitive decline, neuropathy, and an increased risk of neurodegenerative diseases like Parkinson's or dementia

This temporal dissociation suggests that early microglial activation, acting in a neuroprotective fashion, may serve a compensatory or protective role, potentially delaying the onset of clinical symptoms [468]

In addition, activation of the NADPH oxidase is linked to changes in the structure and function of cerebral arterioles that are associated with small vessel disease [49], and to angiotensin II-dependent activation of the enzymatic complex that increased oxidative stress and hypertension in both rats and endothelial cells [43]

VPS9D1-AS1 antisense therapy via lipid nanoparticles reprograms cold tumors and enhances immunotherapy in colorectal cancer