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The damage landscape The damage landscape is dictated by both the ROS species and their location: in lipids, H 2 O 2 -initiated or OH-driven peroxidation generates reactive aldehydes that crosslink proteins and disrupt membrane architecture (Liu et al

Bone , 40, 345353

Despite the fact that the causal association between obesity and chronodisruption is bi-directional (Bray and Young 2012), melatonin and its agonists administration have proven to be effective in circadian rhythm resetting (Zawilska et al

In prostate cancer cells, phenethyl isothiocyanate, a phytochemical found in large amounts in cruciferous vegetables, was reported to restore expression of silenced GSTP1 by a mechanism involving promoter demethylation and increased histone acetylation