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These patients experience accumulation of plasma acylcarnitines, in part due to a decreased renal clearance of esterified carnitine moieties [54]

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[13] Activation [edit] Carnitine shuttle activation occurs due to a need for fatty acid oxidation which is required for energy production

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Studies providing month-long oral supplementation of 2 g of L-carnitine per day to long-distance runners (which consume large amounts of carbohydrates for training) showed a ~10% increase in skeletal muscle carnitine content [25, 26]