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Specificities related to organs and tissues undergoing fibrotic changes are being unraveled by omics studies at single-cell level and are revealing the presence of rare cell types with specific phenotypic and functional characteristics [91]

In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

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