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doi: 10.1371/journal.pone.0233375

619 Overall, DNA methylation levels decrease in SLE patients, and disease activity and progression in lupus patients are negatively correlated with methylation patterns, 620,621 primarily due to the reduced expression/activity of DNMTs

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doi:10.1201/9780429279843-10

rather, elevated levels may reflect the activity of binding proteins or changes in how the body processes B12
