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Nature 174:689691 [DOI] [PubMed] [Google Scholar] Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mecahanisms, mutation, and disease

Notably, the liver is a major target organ for the metabolic effects of insulin and exerts a first-pass extraction of up to 85% of insulin delivered by the portal vein ( Figure 1A )

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According to the latest statistics from the International Agency for Research on Cancer, the estimated number of new cancer cases worldwide in 2020 was around 20 million, with nearly 10 million deaths due to cancer

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