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doi: 10.1080/10408398.2011.555018

Beta-amyloid accumulation in the brain is currently the most commonly accepted hypothesis for the onset of AD pathology, but findings that beta-amyloid is also found in the brain of healthy older adults and that the association between beta-amyloid load and dementia symptoms lessens with age support the contribution of other factors, such as tau accumulation, inflammation, as well as metabolic and cardiovascular factors (106, 112)