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Poly (I:C) treatment at concentrations ranging from 0 to 80 g/mL did not result in cytotoxicity

doi: 10.1038/nrrheum.2015.172 36 WymanBPerlA

Furthermore, in vivo models suggest that intratesticular or peritesticular injections of PRP may promote spermatogenesis, restore testicular architecture, and mitigate damage caused by toxins, ischemiareperfusion injury, or diabetes-induced degeneration [35,36,37,38]

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BBB dysfunction can cause an accumulation of toxic substances in the interstitial fluid surrounding neurons and glial cells