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This can be problematic for people with certain health conditions or older adults whose digestive efficiency may be compromised

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A two-stage open-label Phase III study conducted by Besse B et al

Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)

Whilst occasional constipation is common and often resolves with dietary and lifestyle modifications, certain features should prompt you to contact your GP