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For the assessment of kidney injury severity (severity score), HE stained section images at 10 and 20 (2 at each magnification, for a total of 4 images per mouse) were graded from 0 (no damage) to 5 (most severe damage observed across the samples analyzed), based on the following parameters: (i) protein cast formation, (ii) visible tubular dilation, (iii) loss of proximal tubular cell polarization (no visible brush-border membranes) (iv) area affected (with single nephron damage to majority of the cortex with visual signs of injury)

Studies have also demonstrated dose dependency for this association

Tambm conhecida como vitamina B11, a L-carnitina produzida naturalmente pelo corpo, bem como adquirida no consumo de determinados alimentos, especialmente os de origem animal

Xing L, Shieh HS, Selness SR, Devraj RV, Walker JK, Devadas B, et al

doi: 10.1161/CIRCRESAHA.116.305360 111 SalzanoACassambaiSYazakiYIsrarMZBerniehDWongMet al