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Interestingly, after a week-long suppression of the gut microbiota with oral broad-spectrum antibiotics cocktail, a rechallenge with oral d 9 -BB showed complete suppression of d 9 -TMAO formation in subjects, confirming gut microbiotadependent conversion of BB into TMAO (Figure 2A, open circles)

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The potential mechanisms underlying the beneficial effects were discussed

Glutathione is involved in cellular metabolism and oxidizes easily

B12 is involved in fatty acid metabolism that builds an insulating lipid-rich layer surrounding a neurons axon (the myelin sheath), which speeds up nerve signals and enhances learning and logical thinking processes