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The injection is given intramuscularly, meaning it is injected into a muscle, usually in the upper arm or thigh

The NADPH enzyme is responsible for reducing CU to dihydrocurcumin, which can further convert to tetrahydrocurcumin within the reduction pathway (Wang et al., 2021)

Neuropathic pain in diabetesEvidence for a central mechanism

Side effects of ALA in supplement form are generally rare, but for some people they can include: insomnia fatigue diarrhea skin rash low blood sugar levels (especially in people with diabetes or low blood sugar who take medications) Alpha lipoic acid supplements havent been studied in children or women who are pregnant or breastfeeding, so right now theyre intended for use in adults only

LDL cholesterol often improves, though changes vary by individual