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139 The causal relationship between use of acetaminophen and the occurrence of asthma has been questioned, 140 but the consensus is that a relationship exists 141,142 and a population-wide increase in asthma of more than 40% may be caused by the use of acetaminophen

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Additionally, in a mouse model of permanent middle cerebral artery occlusion-induced cerebral ischemia, mice lacking CP exhibit an increased area of cerebral infarction, leading to more severe oxidative stress damage to lipids and proteins (Ryan et al., 2019)