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In addition to detecting peptides from several proteins previously associated with IC/BPS, we also identified peptides from several proteins that have not been previously implicated in this disorder
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Safety of nivolumab added to chemoradiotherapy platforms for intermediate and high-risk local-regionally advanced head and neck squamous cell carcinoma: RTOG Foundation 3504

This blocks the cellular uptake mechanism FOXO4-DRI relies on, trapping the peptide in circulation where its more vulnerable to protease degradation
