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First of all, baseline folic acid levels were different between studies (7.7 ng/mL for CSPPT renal sub study, 15 and 16.5 ng/mL for DIVINe and HOST study respectively) corroborating the hypothesis that beneficial effects of folic acid supplementation on renal outcomes could be stronger in patients with low folic acid level at baseline

Since vitamin B12 is water soluble, portions not metabolized by the body will be eliminated via urination

Even a minor deficiency of B6 can lead to a significant reduction in neurotransmitter levels

Most protocols recommend a 2 to 4 week break between cycles