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The ugly duckling sign of dermoscopy allows the identification of a second melanoma (c) compared with the predominant nevus pattern of the patient (a, b, d, e) Digital Dermoscopy Follow-Up for the Diagnosis of Melanoma in High-Risk Patients The importance of surveillance by digital dermoscopy follow-up programs to identify melanoma at an early stage in high-risk populations such as patients with hundreds of nevi, atypical mole syndrome (AMS), personal or family history of melanoma, and carriers of genetic mutations as in CDKN2A has been clearly demonstrated [14, 46] (Fig
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The neoplastic cells were immune-positive for S-100, Melan-A and HMB-45 and immune-negative for MNF116 and AE1/3
